Apoptosis Inducing Factor

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

Also Known As:

AIF Apoptosis Regulatory Protein; Apoptosis-Inducing Factor; Mitochondrial Apoptosis-Inducing Factor; Apoptosis-Inducing Factor, Mitochondrial; Mitochondrial Apoptosis Inducing Factor

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - NADPH Oxidoreductases NADH
      - Apoptosis Inducing Factor: 487
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Poly-ADP-Ribose Binding Proteins
      - Apoptosis Inducing Factor: 487
  - Nuclear Proteins: 2678
    - Poly-ADP-Ribose Binding Proteins
      - Apoptosis Inducing Factor: 487
  - Flavoproteins: 234
    - Apoptosis Inducing Factor: 487
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - Apoptosis Inducing Factor: 487
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - Apoptosis Inducing Factor: 487

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Anna Sheydina Research Topics

Disease

Drug/Important Bio-Agent (IBA)